Drug interactions
Dolasetron + Ziprasidone
Severity: Contraindicated
Dolasetron and Ziprasidone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone is among the antipsychotics with notable QT prolongation, and it is contraindicated with other QT-prolonging drugs. Combined with dolasetron the risk of torsades de pointes is increased.
What this interaction means in plain words
Dolasetron and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dolasetron belongs to Gastrointestinal Tract; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive blockade of cardiac repolarizing potassium currents causing QT prolongation.
What to do
Avoid the combination and use an antiemetic without QT effect. If an antiemetic is essential, consider a different agent and monitor ECG and electrolytes.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Dolasetron with Ziprasidone?
MediHelp rates the interaction as contraindicated. Dolasetron and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ziprasidone is among the antipsychotics with notable QT prolongation, and it is contraindicated with other QT-prolonging drugs. Combined with dolasetron the risk of torsades de pointes is increased.
How serious is the interaction between Dolasetron and Ziprasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an antiemetic without QT effect. If an antiemetic is essential, consider a different agent and monitor ECG and electrolytes.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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