Interazioni tra farmaci
Domperidone + Lansoprazole
Gravità: Moderata
Domperidone and Lansoprazole: moderate interaction.
Ultimo aggiornamento Fonti: US FDA label
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Sintesi
Long-term lansoprazole use can cause hypomagnesemia, and low magnesium (often with low potassium) increases susceptibility to QT prolongation and torsades de pointes with domperidone. The risk is mainly seen with prolonged PPI therapy and is greatest in older patients, those on diuretics or digoxin, and those with structural heart disease or other QT-prolonging drugs. The interaction is indirect and uncommon but potentially serious.
Cosa significa questa interazione in parole semplici
Domperidone and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Domperidone belongs to Gastrointestinal Tract; Lansoprazole belongs to Gastrointestinal Tract.
Perché avviene
Pharmacodynamic and indirect: PPI-induced hypomagnesemia (reduced intestinal magnesium absorption) lowers the repolarisation reserve, potentiating the QT-prolonging hERG-blocking effect of domperidone.
Cosa fare
Check magnesium and potassium before starting domperidone in patients on long-term lansoprazole, and correct deficits. Use the lowest effective domperidone dose for the shortest time (labelling advises a maximum of 30 mg/day and about one week for nausea/vomiting).
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Riferimenti
- Prevacid (lansoprazole) Prescribing Information - Warnings: Hypomagnesemia — FDA Label
- Domperidone - Summary of Product Characteristics: Cardiac effects and QT prolongation — EMA SmPC
- PRAC recommendation: Domperidone-containing medicines - restricted use (2014) — EMA
Altre interazioni di Domperidone
- Azithromycin + Domperidone Controindicata
- Domperidone + Erythromycin Controindicata
- Dexlansoprazole + Domperidone Moderata
- Domperidone + Pantoprazole Moderata
- Domperidone + Polyethylene Glycol 3350 Moderata
- Domperidone + Rabeprazole Moderata
Altre interazioni di Lansoprazole
- Lansoprazole + Mavacamten Controindicata
- Lansoprazole + Rilpivirine Controindicata
- Acalabrutinib + Lansoprazole Maggiore
- Atazanavir + Lansoprazole Maggiore
- Dacomitinib + Lansoprazole Maggiore
- Dasatinib + Lansoprazole Maggiore
Domande frequenti
Can I take Domperidone with Lansoprazole?
MediHelp rates the interaction as moderate. Domperidone and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Long-term lansoprazole use can cause hypomagnesemia, and low magnesium (often with low potassium) increases susceptibility to QT prolongation and torsades de pointes with domperidone. The risk is mainly seen with prolonged PPI therapy and is greatest in older patients, those on diuretics or digoxin, and those with structural heart disease or other QT-prolonging drugs. The interaction is indirect and uncommon but potentially serious.
How serious is the interaction between Domperidone and Lansoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check magnesium and potassium before starting domperidone in patients on long-term lansoprazole, and correct deficits. Use the lowest effective domperidone dose for the shortest time (labelling advises a maximum of 30 mg/day and about one week for nausea/vomiting).
What other medicines interact with Domperidone?
MediHelp also lists interactions of Domperidone with, for example, Azithromycin, Erythromycin, Dexlansoprazole. The full list is on the Domperidone page.
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