Interazioni tra farmaci
Domperidone + Polyethylene Glycol 3350
Gravità: Moderata
Domperidone and Polyethylene Glycol 3350: moderate interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
There is no direct interaction, but excessive polyethylene glycol use that causes persistent diarrhea can lead to hypokalemia and hypomagnesemia. Electrolyte disturbance is a recognised risk factor for QT prolongation and torsades de pointes with domperidone. The concern is conditional and relevant mainly to high-risk patients.
Cosa significa questa interazione in parole semplici
Domperidone and Polyethylene Glycol 3350 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perché avviene
Pharmacodynamic and indirect: laxative-induced fluid and electrolyte loss lowers potassium and magnesium, which potentiates the QT-prolonging effect of domperidone. No pharmacokinetic interaction is expected.
Cosa fare
Use PEG at the lowest effective dose and stop or reduce it if diarrhea develops. Check and correct potassium and magnesium in patients with persistent diarrhea who take domperidone.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Domperidone e Polyethylene Glycol 3350, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Riferimenti
- Domperidone Summary of Product Characteristics - Special warnings and precautions (cardiovascular effects, electrolyte disturbances) — EMA SmPC
- Domperidone: risks of cardiac side effects - restricted indications, new contraindications, and reduced dose and duration of use — MHRA Drug Safety Update
Altre interazioni di Domperidone
- Azithromycin + Domperidone Controindicata
- Domperidone + Erythromycin Controindicata
- Dexlansoprazole + Domperidone Moderata
- Domperidone + Lansoprazole Moderata
- Domperidone + Pantoprazole Moderata
- Domperidone + Rabeprazole Moderata
Domande frequenti
Can I take Domperidone with Polyethylene Glycol 3350?
MediHelp rates the interaction as moderate. Domperidone and Polyethylene Glycol 3350 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. There is no direct interaction, but excessive polyethylene glycol use that causes persistent diarrhea can lead to hypokalemia and hypomagnesemia. Electrolyte disturbance is a recognised risk factor for QT prolongation and torsades de pointes with domperidone. The concern is conditional and relevant mainly to high-risk patients.
How serious is the interaction between Domperidone and Polyethylene Glycol 3350?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use PEG at the lowest effective dose and stop or reduce it if diarrhea develops. Check and correct potassium and magnesium in patients with persistent diarrhea who take domperidone.
What other medicines interact with Domperidone?
MediHelp also lists interactions of Domperidone with, for example, Azithromycin, Erythromycin, Dexlansoprazole. The full list is on the Domperidone page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
