Interazioni tra farmaci
Levoketoconazole + Methadone
Gravità: Controindicata
Levoketoconazole and Methadone: contraindicated interaction.
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Sintesi
Levoketoconazole strongly inhibits CYP3A4 and prolongs the QT interval, and methadone shares both features of risk. The combination can increase methadone concentrations and the risk of torsades de pointes and respiratory depression.
Cosa significa questa interazione in parole semplici
Levoketoconazole and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levoketoconazole belongs to Endocrine; Methadone belongs to Musculoskeletal.
Perché avviene
CYP3A4 inhibition raises methadone exposure, with additive QT prolongation.
Cosa fare
Do not use together; consider an alternative treatment for hypercortisolism or opioid therapy. Correct electrolytes and monitor ECG if the combination cannot be avoided.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Methadone
- Alvimopan + Methadone Controindicata
- Calcium / magnesium / potassium / sodium oxybates + Methadone Controindicata
- Droperidol + Methadone Controindicata
- Ibutilide + Methadone Controindicata
- Isocarboxazid + Methadone Controindicata
- Lefamulin + Methadone Controindicata
Altre interazioni di Levoketoconazole
- Alfuzosin + Levoketoconazole Controindicata
- Alprazolam + Levoketoconazole Controindicata
- Amiodarone + Levoketoconazole Controindicata
- Avanafil + Levoketoconazole Controindicata
- Cisapride + Levoketoconazole Controindicata
- Clarithromycin + Levoketoconazole Controindicata
Domande frequenti
Can I take Levoketoconazole with Methadone?
MediHelp rates the interaction as contraindicated. Levoketoconazole and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole strongly inhibits CYP3A4 and prolongs the QT interval, and methadone shares both features of risk. The combination can increase methadone concentrations and the risk of torsades de pointes and respiratory depression.
How serious is the interaction between Levoketoconazole and Methadone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; consider an alternative treatment for hypercortisolism or opioid therapy. Correct electrolytes and monitor ECG if the combination cannot be avoided.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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