Interazioni tra farmaci
Droperidol + Nilotinib
Gravità: Controindicata
Droperidol and Nilotinib: contraindicated interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Nilotinib and droperidol each prolong the QT interval, and together the effect is additive. Droperidol carries a boxed warning for QT prolongation and torsades de pointes, so adding nilotinib increases the arrhythmia risk substantially.
Cosa significa questa interazione in parole semplici
Droperidol and Nilotinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Additive QT prolongation through blockade of cardiac hERG potassium channels.
Cosa fare
Avoid droperidol in patients taking nilotinib and use an antiemetic with less QT effect, such as a non-QT-prolonging alternative. If unavoidable, use only with continuous ECG monitoring and normal electrolytes.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Droperidol e Nilotinib, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Nilotinib
- Amiodarone + Nilotinib Controindicata
- Arsenic trioxide + Nilotinib Controindicata
- Disopyramide + Nilotinib Controindicata
- Dofetilide + Nilotinib Controindicata
- Dronedarone + Nilotinib Controindicata
- Ibutilide + Nilotinib Controindicata
Domande frequenti
Can I take Droperidol with Nilotinib?
MediHelp rates the interaction as contraindicated. Droperidol and Nilotinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nilotinib and droperidol each prolong the QT interval, and together the effect is additive. Droperidol carries a boxed warning for QT prolongation and torsades de pointes, so adding nilotinib increases the arrhythmia risk substantially.
How serious is the interaction between Droperidol and Nilotinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid droperidol in patients taking nilotinib and use an antiemetic with less QT effect, such as a non-QT-prolonging alternative. If unavoidable, use only with continuous ECG monitoring and normal electrolytes.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
