Vai al contenuto

Interazioni tra farmaci

Arsenic trioxide + Nilotinib

Gravità: Controindicata

Arsenic trioxide and Nilotinib: contraindicated interaction.

Ultimo aggiornamento

Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.

Il contenuto clinico di questa pagina è disponibile solo in inglese.

Sintesi

Both drugs prolong the QT interval, and combining them raises the risk of torsades de pointes and sudden cardiac death. Arsenic trioxide additionally causes electrolyte disturbances that amplify the risk.

Cosa significa questa interazione in parole semplici

Arsenic trioxide and Nilotinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Arsenic trioxide belongs to Oncology; Nilotinib belongs to Oncology.

Livello di evidenza: Moderate

Perché avviene

Additive QT prolongation through cardiac repolarization effects.

Cosa fare

Avoid the combination. If it cannot be avoided, correct potassium and magnesium and perform frequent ECG monitoring.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Per gli utenti Pro+

Sblocca la pagina completa

Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Arsenic trioxide e Nilotinib, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.

Domande frequenti

Can I take Arsenic trioxide with Nilotinib?

MediHelp rates the interaction as contraindicated. Arsenic trioxide and Nilotinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and combining them raises the risk of torsades de pointes and sudden cardiac death. Arsenic trioxide additionally causes electrolyte disturbances that amplify the risk.

How serious is the interaction between Arsenic trioxide and Nilotinib?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If it cannot be avoided, correct potassium and magnesium and perform frequent ECG monitoring.

What other medicines interact with Nilotinib?

MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Disopyramide, Dofetilide. The full list is on the Nilotinib page.

Monografie complete, posologie e verifica delle interazioni nell'app MediHelp

Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.

Sfoglia dalla A alla Z · Interazioni tra farmaci

Scarica l'app Accedi