Interazioni tra farmaci
Efavirenz + Isavuconazonium
Gravità: Controindicata
Efavirenz and Isavuconazonium: contraindicated interaction.
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Sintesi
Efavirenz may reduce isavuconazole concentrations, risking treatment failure of serious invasive fungal infections. Strong inducers are contraindicated with isavuconazonium.
Cosa significa questa interazione in parole semplici
Efavirenz and Isavuconazonium are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Efavirenz belongs to Anti Virals; Isavuconazonium belongs to Anti Fungals.
Perché avviene
Efavirenz induces CYP3A4 metabolism of isavuconazole.
Cosa fare
Avoid the combination; use an alternative antifungal or antiretroviral. If unavoidable, monitor isavuconazole levels and clinical response.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Efavirenz
- Cobimetinib + Efavirenz Controindicata
- Dienogest / estradiol valerate + Efavirenz Controindicata
- Dihydroergotamine intranasal + Efavirenz Controindicata
- Dihydroergotamine + Efavirenz Controindicata
- Doravirine + Efavirenz Controindicata
- Efavirenz + Elbasvir / grazoprevir Controindicata
Altre interazioni di Isavuconazonium
- Amobarbital + Isavuconazonium Controindicata
- Apalutamide + Isavuconazonium Controindicata
- Carbamazepine + Isavuconazonium Controindicata
- Cisapride + Isavuconazonium Controindicata
- Enzalutamide + Isavuconazonium Controindicata
- Isavuconazonium + Ketoconazole Controindicata
Domande frequenti
Can I take Efavirenz with Isavuconazonium?
MediHelp rates the interaction as contraindicated. Efavirenz and Isavuconazonium are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Efavirenz may reduce isavuconazole concentrations, risking treatment failure of serious invasive fungal infections. Strong inducers are contraindicated with isavuconazonium.
How serious is the interaction between Efavirenz and Isavuconazonium?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative antifungal or antiretroviral. If unavoidable, monitor isavuconazole levels and clinical response.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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