Interazioni tra farmaci
Enzalutamide + Isavuconazonium
Gravità: Controindicata
Enzalutamide and Isavuconazonium: contraindicated interaction.
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Sintesi
Isavuconazonium is converted to isavuconazole, a CYP3A4 substrate, and strong inducers markedly reduce its exposure. This can lead to antifungal failure in invasive infections, and labeling contraindicates strong inducers.
Cosa significa questa interazione in parole semplici
Enzalutamide and Isavuconazonium are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Enzalutamide belongs to Endocrine; Isavuconazonium belongs to Anti Fungals.
Perché avviene
Enzalutamide induces CYP3A4 and increases isavuconazole metabolism.
Cosa fare
Do not coadminister; use an alternative antifungal such as liposomal amphotericin B or consider switching the antiandrogen. Monitor clinical response if the inducer was recently stopped.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Enzalutamide
- Doravirine + Enzalutamide Controindicata
- Elbasvir / grazoprevir + Enzalutamide Controindicata
- Ensitrelvir + Enzalutamide Controindicata
- Enzalutamide + Fostemsavir Controindicata
- Enzalutamide + Lenacapavir Controindicata
- Enzalutamide + Lonafarnib Controindicata
Altre interazioni di Isavuconazonium
- Amobarbital + Isavuconazonium Controindicata
- Apalutamide + Isavuconazonium Controindicata
- Carbamazepine + Isavuconazonium Controindicata
- Cisapride + Isavuconazonium Controindicata
- Efavirenz + Isavuconazonium Controindicata
- Isavuconazonium + Ketoconazole Controindicata
Domande frequenti
Can I take Enzalutamide with Isavuconazonium?
MediHelp rates the interaction as contraindicated. Enzalutamide and Isavuconazonium are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isavuconazonium is converted to isavuconazole, a CYP3A4 substrate, and strong inducers markedly reduce its exposure. This can lead to antifungal failure in invasive infections, and labeling contraindicates strong inducers.
How serious is the interaction between Enzalutamide and Isavuconazonium?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antifungal such as liposomal amphotericin B or consider switching the antiandrogen. Monitor clinical response if the inducer was recently stopped.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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