Interazioni tra farmaci
Amobarbital + Isavuconazonium
Gravità: Controindicata
Amobarbital and Isavuconazonium: contraindicated interaction.
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Sintesi
Inducers of CYP3A4 such as barbiturates lower isavuconazole concentrations considerably. Subtherapeutic exposure risks failure of treatment of serious invasive fungal infection. Strong inducers are contraindicated in the labeling.
Cosa significa questa interazione in parole semplici
Amobarbital and Isavuconazonium are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amobarbital belongs to Central Nervous System; Isavuconazonium belongs to Anti Fungals.
Perché avviene
Barbiturate-mediated CYP3A4 induction increases isavuconazole clearance.
Cosa fare
Avoid the combination and choose a non-inducing sedative. If an inducer is essential, consider a different antifungal.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Controindicata
- Amobarbital + Doravirine Controindicata
- Amobarbital + Elbasvir / grazoprevir Controindicata
- Amobarbital + Isocarboxazid Controindicata
- Amobarbital + Lonafarnib Controindicata
- Amobarbital + Lorlatinib Controindicata
Altre interazioni di Isavuconazonium
- Apalutamide + Isavuconazonium Controindicata
- Carbamazepine + Isavuconazonium Controindicata
- Cisapride + Isavuconazonium Controindicata
- Efavirenz + Isavuconazonium Controindicata
- Enzalutamide + Isavuconazonium Controindicata
- Isavuconazonium + Ketoconazole Controindicata
Domande frequenti
Can I take Amobarbital with Isavuconazonium?
MediHelp rates the interaction as contraindicated. Amobarbital and Isavuconazonium are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Inducers of CYP3A4 such as barbiturates lower isavuconazole concentrations considerably. Subtherapeutic exposure risks failure of treatment of serious invasive fungal infection. Strong inducers are contraindicated in the labeling.
How serious is the interaction between Amobarbital and Isavuconazonium?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-inducing sedative. If an inducer is essential, consider a different antifungal.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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