Interazioni tra farmaci
Elagolix + Ketoconazole
Gravità: Maggiore
Elagolix and Ketoconazole: major interaction.
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Sintesi
Strong CYP3A inhibition by ketoconazole increases elagolix exposure, raising the risk of dose-related effects such as bone mineral density loss and liver enzyme elevations. Risk is greater with longer duration of use.
Cosa significa questa interazione in parole semplici
Elagolix and Ketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Elagolix belongs to Musculoskeletal; Ketoconazole belongs to Anti Fungals.
Perché avviene
Ketoconazole inhibits CYP3A4-mediated metabolism of elagolix.
Cosa fare
Avoid long-term use with the 200 mg twice-daily dose; if the combination is needed, limit elagolix to 150 mg once daily and restrict the inhibitor course to a maximum of 6 months.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Ketoconazole
- Alfuzosin + Ketoconazole Controindicata
- Alprazolam + Ketoconazole Controindicata
- Avanafil + Ketoconazole Controindicata
- Conivaptan + Ketoconazole Controindicata
- Dihydroergotamine intranasal + Ketoconazole Controindicata
- Dihydroergotamine + Ketoconazole Controindicata
Altre interazioni di Elagolix
- Cyclosporin + Elagolix Controindicata
- Elagolix + Gemfibrozil Controindicata
- Desogestrel-ethinyl estradiol + Elagolix Maggiore
- Elagolix + Erythromycin Maggiore
- Elagolix + Ethinyl estradiol-drospirenone Maggiore
- Elagolix + Ethinyl estradiol-levonorgestrel Maggiore
Domande frequenti
Can I take Elagolix with Ketoconazole?
MediHelp rates the interaction as major. Elagolix and Ketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A inhibition by ketoconazole increases elagolix exposure, raising the risk of dose-related effects such as bone mineral density loss and liver enzyme elevations. Risk is greater with longer duration of use.
How serious is the interaction between Elagolix and Ketoconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term use with the 200 mg twice-daily dose; if the combination is needed, limit elagolix to 150 mg once daily and restrict the inhibitor course to a maximum of 6 months.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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