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Elagolix + Ethinyl estradiol-drospirenone

Gravità: Maggiore

Elagolix and Ethinyl estradiol-drospirenone: major interaction.

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Sintesi

Estrogen-containing contraceptives are expected to counteract elagolix's hypoestrogenic effect and reduce its efficacy. Elagolix may also lower hormonal contraceptive efficacy and is not itself a reliable contraceptive.

Cosa significa questa interazione in parole semplici

Elagolix and Ethinyl estradiol-drospirenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Elagolix belongs to Musculoskeletal; Ethinyl estradiol-drospirenone belongs to Endocrine.

Livello di evidenza: Moderate

Perché avviene

Pharmacodynamic antagonism: exogenous estrogen opposes elagolix's suppression of estrogen.

Cosa fare

Use non-hormonal contraception during elagolix therapy and for one week after stopping. Avoid concurrent estrogen-containing contraceptives.

Cosa chiedere al farmacista

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Elagolix with Ethinyl estradiol-drospirenone?

MediHelp rates the interaction as major. Elagolix and Ethinyl estradiol-drospirenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Estrogen-containing contraceptives are expected to counteract elagolix's hypoestrogenic effect and reduce its efficacy. Elagolix may also lower hormonal contraceptive efficacy and is not itself a reliable contraceptive.

How serious is the interaction between Elagolix and Ethinyl estradiol-drospirenone?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use non-hormonal contraception during elagolix therapy and for one week after stopping. Avoid concurrent estrogen-containing contraceptives.

What other medicines interact with Ethinyl estradiol-drospirenone?

MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.

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