Interazioni tra farmaci
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin
Gravità: Controindicata
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lovastatin: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
The cobicistat in this fixed-dose regimen is a potent CYP3A4 inhibitor that greatly raises lovastatin levels. This substantially increases the risk of myopathy and rhabdomyolysis, so the combination is contraindicated.
Cosa significa questa interazione in parole semplici
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lovastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Cobicistat inhibits CYP3A4, preventing lovastatin metabolism.
Cosa fare
Do not use together. Use pravastatin or rosuvastatin at the lowest effective dose and monitor for muscle symptoms.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Lovastatin
- Atazanavir + Lovastatin Controindicata
- Clarithromycin + Lovastatin Controindicata
- Cobicistat + Lovastatin Controindicata
- Conivaptan + Lovastatin Controindicata
- Darunavir + Lovastatin Controindicata
- Erythromycin base + Lovastatin Controindicata
Domande frequenti
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Lovastatin?
MediHelp rates the interaction as contraindicated. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lovastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The cobicistat in this fixed-dose regimen is a potent CYP3A4 inhibitor that greatly raises lovastatin levels. This substantially increases the risk of myopathy and rhabdomyolysis, so the combination is contraindicated.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lovastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Use pravastatin or rosuvastatin at the lowest effective dose and monitor for muscle symptoms.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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