Interazioni tra farmaci
Atazanavir + Lovastatin
Gravità: Controindicata
Atazanavir and Lovastatin: contraindicated interaction.
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Sintesi
Atazanavir is a strong CYP3A4 inhibitor and markedly raises lovastatin exposure, with a high risk of myopathy and rhabdomyolysis. Concurrent use is contraindicated.
Cosa significa questa interazione in parole semplici
Atazanavir and Lovastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Atazanavir belongs to Anti Virals; Lovastatin belongs to Cardiovascular.
Perché avviene
Atazanavir inhibits CYP3A4, blocking the first-pass and systemic metabolism of lovastatin.
Cosa fare
Do not combine. Use a statin less dependent on CYP3A4, such as pravastatin or rosuvastatin, at a suitable dose.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Lovastatin
- Clarithromycin + Lovastatin Controindicata
- Cobicistat + Lovastatin Controindicata
- Conivaptan + Lovastatin Controindicata
- Darunavir + Lovastatin Controindicata
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Controindicata
- Erythromycin base + Lovastatin Controindicata
Altre interazioni di Atazanavir
- Alfuzosin + Atazanavir Controindicata
- Atazanavir + Avanafil Controindicata
- Atazanavir + Dronedarone Controindicata
- Atazanavir + Eletriptan Controindicata
- Atazanavir + Eplerenone Controindicata
- Atazanavir + Ergotamine Controindicata
Domande frequenti
Can I take Atazanavir with Lovastatin?
MediHelp rates the interaction as contraindicated. Atazanavir and Lovastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Atazanavir is a strong CYP3A4 inhibitor and markedly raises lovastatin exposure, with a high risk of myopathy and rhabdomyolysis. Concurrent use is contraindicated.
How serious is the interaction between Atazanavir and Lovastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use a statin less dependent on CYP3A4, such as pravastatin or rosuvastatin, at a suitable dose.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Clarithromycin, Cobicistat, Conivaptan. The full list is on the Lovastatin page.
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