Interazioni tra farmaci
Clarithromycin + Lovastatin
Gravità: Controindicata
Clarithromycin and Lovastatin: contraindicated interaction.
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Sintesi
Clarithromycin is a strong CYP3A4 inhibitor, and lovastatin depends almost entirely on CYP3A4 for clearance. Exposure rises many-fold, leading to myopathy and rhabdomyolysis.
Cosa significa questa interazione in parole semplici
Clarithromycin and Lovastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Lovastatin belongs to Cardiovascular.
Perché avviene
CYP3A4 inhibition by clarithromycin reduces first-pass and systemic clearance of lovastatin
Cosa fare
Do not combine; choose an alternative to clarithromycin or a statin that is not CYP3A4-dependent such as pravastatin or rosuvastatin, withholding the statin if the macrolide is essential.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Clarithromycin
- Astemizole + Clarithromycin Controindicata
- Avanafil + Clarithromycin Controindicata
- Cisapride + Clarithromycin Controindicata
- Clarithromycin + Colchicine Controindicata
- Clarithromycin + Conivaptan Controindicata
- Clarithromycin + Dihydroergotamine Controindicata
Altre interazioni di Lovastatin
- Atazanavir + Lovastatin Controindicata
- Cobicistat + Lovastatin Controindicata
- Conivaptan + Lovastatin Controindicata
- Darunavir + Lovastatin Controindicata
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Controindicata
- Erythromycin base + Lovastatin Controindicata
Domande frequenti
Can I take Clarithromycin with Lovastatin?
MediHelp rates the interaction as contraindicated. Clarithromycin and Lovastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin is a strong CYP3A4 inhibitor, and lovastatin depends almost entirely on CYP3A4 for clearance. Exposure rises many-fold, leading to myopathy and rhabdomyolysis.
How serious is the interaction between Clarithromycin and Lovastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose an alternative to clarithromycin or a statin that is not CYP3A4-dependent such as pravastatin or rosuvastatin, withholding the statin if the macrolide is essential.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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