Interazioni tra farmaci
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Valacyclovir
Gravità: Moderata
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Valacyclovir: moderate interaction.
Ultimo aggiornamento
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Sintesi
Acyclovir, formed from valacyclovir, emtricitabine and tenofovir are all cleared by renal filtration and tubular secretion. Co-administration can raise levels of each and tenofovir adds nephrotoxic potential.
Cosa significa questa interazione in parole semplici
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perché avviene
Competition for renal tubular secretion plus additive nephrotoxicity, and cobicistat further reduces tubular creatinine secretion.
Cosa fare
Monitor serum creatinine, phosphate and urinalysis regularly. Adjust the valacyclovir dose to renal function and stop the combination if renal function worsens.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Valacyclovir
- Talimogene laherparepvec + Valacyclovir Maggiore
- Bacitracin + Valacyclovir Moderata
- Cilastatin-imipenem + Valacyclovir Moderata
- Imipenem / cilastatin / relebactam + Valacyclovir Moderata
- Imipenem / cilastatin + Valacyclovir Moderata
- Mycophenolic acid + Valacyclovir Moderata
Domande frequenti
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Valacyclovir?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Acyclovir, formed from valacyclovir, emtricitabine and tenofovir are all cleared by renal filtration and tubular secretion. Co-administration can raise levels of each and tenofovir adds nephrotoxic potential.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Valacyclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate and urinalysis regularly. Adjust the valacyclovir dose to renal function and stop the combination if renal function worsens.
What other medicines interact with Valacyclovir?
MediHelp also lists interactions of Valacyclovir with, for example, Talimogene laherparepvec, Bacitracin, Cilastatin-imipenem. The full list is on the Valacyclovir page.
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