Interazioni tra farmaci
Talimogene laherparepvec + Valacyclovir
Gravità: Maggiore
Talimogene laherparepvec and Valacyclovir: major interaction.
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Sintesi
Talimogene laherparepvec is a live attenuated herpes simplex virus that must replicate to be effective. Antiherpetic antivirals may suppress its replication and reduce efficacy.
Cosa significa questa interazione in parole semplici
Talimogene laherparepvec and Valacyclovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Talimogene laherparepvec belongs to Oncology; Valacyclovir belongs to Anti Virals.
Perché avviene
Valacyclovir's active form acyclovir inhibits herpes viral DNA polymerase, which may block replication of the oncolytic virus.
Cosa fare
Avoid antiherpetic agents during talimogene therapy unless needed to treat herpetic infection. Review the need for valacyclovir before each treatment.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Valacyclovir
- Bacitracin + Valacyclovir Moderata
- Cilastatin-imipenem + Valacyclovir Moderata
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Valacyclovir Moderata
- Imipenem / cilastatin / relebactam + Valacyclovir Moderata
- Imipenem / cilastatin + Valacyclovir Moderata
- Mycophenolic acid + Valacyclovir Moderata
Altre interazioni di Talimogene laherparepvec
- Ifosfamide + Talimogene laherparepvec Controindicata
- Acyclovir + Talimogene laherparepvec Maggiore
- Famciclovir + Talimogene laherparepvec Maggiore
- Ganciclovir + Talimogene laherparepvec Maggiore
- Talimogene laherparepvec + Valganciclovir Maggiore
Domande frequenti
Can I take Talimogene laherparepvec with Valacyclovir?
MediHelp rates the interaction as major. Talimogene laherparepvec and Valacyclovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Talimogene laherparepvec is a live attenuated herpes simplex virus that must replicate to be effective. Antiherpetic antivirals may suppress its replication and reduce efficacy.
How serious is the interaction between Talimogene laherparepvec and Valacyclovir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid antiherpetic agents during talimogene therapy unless needed to treat herpetic infection. Review the need for valacyclovir before each treatment.
What other medicines interact with Valacyclovir?
MediHelp also lists interactions of Valacyclovir with, for example, Bacitracin, Cilastatin-imipenem, Elvitegravir / cobicistat / emtricitabine / tenofovir df. The full list is on the Valacyclovir page.
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