Interazioni tra farmaci
Fluoxetine + Pimozide
Gravità: Controindicata
Fluoxetine and Pimozide: contraindicated interaction.
Ultimo aggiornamento Fonti: US FDA label
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Fluoxetine inhibits CYP2D6 and CYP3A4 and can raise pimozide concentrations, increasing the risk of QT prolongation and torsades de pointes. Both product labels contraindicate the combination. The effect is dose-related and most dangerous in people with cardiac disease, electrolyte disturbances or CYP2D6 poor metaboliser status.
Cosa significa questa interazione in parole semplici
Fluoxetine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluoxetine belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Perché avviene
Fluoxetine and norfluoxetine inhibit CYP2D6 and to a lesser extent CYP3A4, reducing pimozide clearance, and both drugs may have additive effects on cardiac repolarisation.
Cosa fare
Do not co-administer. Use an alternative antidepressant or antipsychotic without QT or CYP-inhibitory interaction, and obtain an ECG and correct potassium and magnesium if either drug has recently been taken.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Fluoxetine e Pimozide, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Riferimenti
Altre interazioni di Fluoxetine
- Fluoxetine + Isocarboxazid Controindicata
- Fluoxetine + Mavacamten Controindicata
- Fluoxetine + Methylene blue Controindicata
- Fluoxetine + Phenelzine Controindicata
- Fluoxetine + Rasagiline Controindicata
- Fluoxetine + Selegiline Controindicata
Altre interazioni di Pimozide
- Adagrasib + Pimozide Controindicata
- Amiodarone + Pimozide Controindicata
- Amisulpride + Pimozide Controindicata
- Amitriptyline + Pimozide Controindicata
- Amoxapine + Pimozide Controindicata
- Anagrelide + Pimozide Controindicata
Domande frequenti
Can I take Fluoxetine with Pimozide?
MediHelp rates the interaction as contraindicated. Fluoxetine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fluoxetine inhibits CYP2D6 and CYP3A4 and can raise pimozide concentrations, increasing the risk of QT prolongation and torsades de pointes. Both product labels contraindicate the combination. The effect is dose-related and most dangerous in people with cardiac disease, electrolyte disturbances or CYP2D6 poor metaboliser status.
How serious is the interaction between Fluoxetine and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Use an alternative antidepressant or antipsychotic without QT or CYP-inhibitory interaction, and obtain an ECG and correct potassium and magnesium if either drug has recently been taken.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
