Interazioni tra farmaci
Fluoxetine + Selegiline
Gravità: Controindicata
Fluoxetine and Selegiline: contraindicated interaction.
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Sintesi
Selegiline inhibits MAO-B and loses selectivity at higher doses, and fluoxetine inhibits serotonin reuptake. Serotonin syndrome has been reported, and fluoxetine also inhibits CYP2D6, raising selegiline exposure.
Cosa significa questa interazione in parole semplici
Fluoxetine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluoxetine belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Perché avviene
MAO inhibition plus serotonin reuptake inhibition; CYP inhibition raises selegiline levels
Cosa fare
Do not use together; allow at least 5 weeks after stopping fluoxetine before starting selegiline, and 14 days after stopping selegiline before starting fluoxetine.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Fluoxetine
- Fluoxetine + Isocarboxazid Controindicata
- Fluoxetine + Mavacamten Controindicata
- Fluoxetine + Methylene blue Controindicata
- Fluoxetine + Phenelzine Controindicata
- Fluoxetine + Pimozide Controindicata
- Fluoxetine + Rasagiline Controindicata
Altre interazioni di Selegiline
- Amitriptyline + Selegiline Controindicata
- Amoxapine + Selegiline Controindicata
- Atomoxetine + Selegiline Controindicata
- Benzphetamine + Selegiline Controindicata
- Brimonidine + Selegiline Controindicata
- Buprenorphine long-acting + Selegiline Controindicata
Domande frequenti
Can I take Fluoxetine with Selegiline?
MediHelp rates the interaction as contraindicated. Fluoxetine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline inhibits MAO-B and loses selectivity at higher doses, and fluoxetine inhibits serotonin reuptake. Serotonin syndrome has been reported, and fluoxetine also inhibits CYP2D6, raising selegiline exposure.
How serious is the interaction between Fluoxetine and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; allow at least 5 weeks after stopping fluoxetine before starting selegiline, and 14 days after stopping selegiline before starting fluoxetine.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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