Interazioni tra farmaci
Fluvastatin + Gemfibrozil
Gravità: Maggiore
Fluvastatin and Gemfibrozil: major interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Gemfibrozil inhibits OATP1B1 and glucuronidation and fibrates also have intrinsic myotoxicity, which can raise statin exposure. Fluvastatin is mainly cleared by CYP2C9, so the pharmacokinetic rise is smaller than for other statins, but myopathy and rhabdomyolysis remain possible.
Cosa significa questa interazione in parole semplici
Fluvastatin and Gemfibrozil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluvastatin belongs to Cardiovascular; Gemfibrozil belongs to Cardiovascular.
Perché avviene
Additive myotoxicity with possible OATP1B1 inhibition
Cosa fare
Avoid where possible; if both are needed use the lowest fluvastatin dose, and advise patients to report muscle pain or dark urine; check CK if symptomatic.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Fluvastatin e Gemfibrozil, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Fluvastatin
- Cyclosporine + Fluvastatin Maggiore
- Cyclosporin + Fluvastatin Maggiore
- Fluvastatin + Letermovir Maggiore
- Fluvastatin + Red yeast rice Maggiore
- Apalutamide + Fluvastatin Moderata
- Cholestyramine + Fluvastatin Moderata
Altre interazioni di Gemfibrozil
- Daprodustat + Gemfibrozil Controindicata
- Elagolix + Gemfibrozil Controindicata
- Gemfibrozil + Mavacamten Controindicata
- Gemfibrozil + Metformin-repaglinide Controindicata
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Controindicata
- Gemfibrozil + Repaglinide Controindicata
Domande frequenti
Can I take Fluvastatin with Gemfibrozil?
MediHelp rates the interaction as major. Fluvastatin and Gemfibrozil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gemfibrozil inhibits OATP1B1 and glucuronidation and fibrates also have intrinsic myotoxicity, which can raise statin exposure. Fluvastatin is mainly cleared by CYP2C9, so the pharmacokinetic rise is smaller than for other statins, but myopathy and rhabdomyolysis remain possible.
How serious is the interaction between Fluvastatin and Gemfibrozil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where possible; if both are needed use the lowest fluvastatin dose, and advise patients to report muscle pain or dark urine; check CK if symptomatic.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Letermovir. The full list is on the Fluvastatin page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
