Interazioni tra farmaci
Fluvastatin + Letermovir
Gravità: Maggiore
Fluvastatin and Letermovir: major interaction.
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Sintesi
Letermovir inhibits OATP1B1/3 and raises exposure of many statins, and fluvastatin concentrations may also increase. This raises the risk of myopathy and rhabdomyolysis, and use is not recommended when cyclosporine is also given.
Cosa significa questa interazione in parole semplici
Fluvastatin and Letermovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluvastatin belongs to Cardiovascular; Letermovir belongs to Anti Virals.
Perché avviene
Letermovir inhibits OATP1B1/3 hepatic uptake and possibly BCRP, increasing fluvastatin exposure.
Cosa fare
Consider reducing the fluvastatin dose and monitor closely for muscle symptoms. Avoid fluvastatin if the patient also receives cyclosporine.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Fluvastatin
- Cyclosporine + Fluvastatin Maggiore
- Cyclosporin + Fluvastatin Maggiore
- Fluvastatin + Gemfibrozil Maggiore
- Fluvastatin + Red yeast rice Maggiore
- Apalutamide + Fluvastatin Moderata
- Cholestyramine + Fluvastatin Moderata
Altre interazioni di Letermovir
- Ergotamine + Letermovir Controindicata
- Letermovir + Pimozide Controindicata
- Apalutamide + Letermovir Maggiore
- Atorvastatin + Letermovir Maggiore
- Carbamazepine + Letermovir Maggiore
- Colchicine + Letermovir Maggiore
Domande frequenti
Can I take Fluvastatin with Letermovir?
MediHelp rates the interaction as major. Fluvastatin and Letermovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Letermovir inhibits OATP1B1/3 and raises exposure of many statins, and fluvastatin concentrations may also increase. This raises the risk of myopathy and rhabdomyolysis, and use is not recommended when cyclosporine is also given.
How serious is the interaction between Fluvastatin and Letermovir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the fluvastatin dose and monitor closely for muscle symptoms. Avoid fluvastatin if the patient also receives cyclosporine.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Fluvastatin page.
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