Riferimento farmaci
Fluvastatin
Fluvastatin is a medicine in the class cardiovascular. It is used for dyslipidemia.
- Classe del farmaco: Cardiovascular
- Indicato per: dyslipidemia
Ultimo aggiornamento
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In breve
- Classe del farmaco
- Cardiovascular
- Forme farmaceutiche comuni
- compressa, capsula
- Dosaggi comuni
- 80 mg, 40 mg
- Interazioni note
- 126 (Maggiore: 5 · Moderata: 52 · Minore: 69)
- Nomi commerciali
- 8
- Paesi e mercati
- 5
Per cosa si usa
Come agisce
HMG-CoA reductase inhibitor, inhibits the rate-limiting step in cholesterol biosynthesis by competitively inhibiting HMG-CoA reductase
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Hypercholesterolemia & Mixed Dyslipidemia: Start 20-40 mg PO qHS, Dose range 20-80 mg PO qDay
Come si assume di solito
Statins are taken by mouth once a day, long term, with blood tests to check the response and liver function.
Gravidanza e allattamento
- Gravidanza
- Unsafe EU/UK labels and the old-format US capsule label contraindicate it in pregnancy (reduced fetal cholesterol synthesis); the current US ER label (2023) says stop when pregnancy is recognised unless the need is compelling. Statin data show no rise in birth defects. Stop before or when pregnant.
- Allattamento
- Unsafe No human milk data; it passes into rat milk (milk-to-plasma ratio 2:1). US label: contraindicated while breastfeeding because of possible effects on infant lipid metabolism. LactMed: avoid; an alternative is preferred.
Effetti indesiderati segnalati
- Headache
- Fatigue
- Diarrhea
- Insomnia
- Abdominal pain
- Dyspepsia
Chi deve prestare attenzione
- Lipid-lowering effects additive with bile-acid binding resin or niacin
- Rare reports of immune-mediated necrotizing myopathy (IMNM), characterized by increased serum creatine kinase that persist despite discontinuing statin
- Heavy alcohol use, history of liver disease, renal failure
Unexplained muscle pain, tenderness or weakness while taking a statin should be reported promptly. Statins are not used in pregnancy, and some other medicines raise their levels and risk.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (126)
- Cyclosporin + Fluvastatin Major
- Cyclosporine + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
- Colchicine + Fluvastatin Moderate
- Colestipol + Fluvastatin Moderate
- Danicopan + Fluvastatin Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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Altri farmaci della stessa classe
Domande frequenti
What is Fluvastatin used for?
Fluvastatin is a medicine in the class cardiovascular. It is used for Dyslipidemia, Hypercholesterolemia.
What side effects have been reported with Fluvastatin?
Headache, Fatigue, Diarrhea, Insomnia, Abdominal pain, Dyspepsia.
Can Fluvastatin be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. EU/UK labels and the old-format US capsule label contraindicate it in pregnancy (reduced fetal cholesterol synthesis); the current US ER label (2023) says stop when pregnancy is recognised unless the need is compelling. Statin data show no rise in birth defects. Stop before or when pregnant. Breastfeeding: Unsafe. No human milk data; it passes into rat milk (milk-to-plasma ratio 2:1). US label: contraindicated while breastfeeding because of possible effects on infant lipid metabolism. LactMed: avoid; an alternative is preferred.
What does Fluvastatin interact with?
MediHelp lists 126 known interactions for Fluvastatin. Major: 5 · Moderate: 52 · Minor: 69. The most serious include Cyclosporin, Cyclosporine, Gemfibrozil.
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