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Interazioni tra farmaci

Foscarnet + Thioridazine

Gravità: Controindicata

Foscarnet and Thioridazine: contraindicated interaction.

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Sintesi

Thioridazine is strongly associated with QT prolongation and torsades de pointes, and foscarnet adds further QT risk and electrolyte depletion. The combination carries a high risk of life-threatening arrhythmia.

Cosa significa questa interazione in parole semplici

Foscarnet and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Foscarnet belongs to Anti Virals; Thioridazine belongs to Central Nervous System.

Livello di evidenza: Moderate

Perché avviene

Additive QT prolongation, with foscarnet-related hypocalcemia and hypomagnesemia increasing susceptibility.

Cosa fare

Avoid the combination and choose an antipsychotic with lower QT liability.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Foscarnet with Thioridazine?

MediHelp rates the interaction as contraindicated. Foscarnet and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine is strongly associated with QT prolongation and torsades de pointes, and foscarnet adds further QT risk and electrolyte depletion. The combination carries a high risk of life-threatening arrhythmia.

How serious is the interaction between Foscarnet and Thioridazine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antipsychotic with lower QT liability.

What other medicines interact with Foscarnet?

MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Vandetanib. The full list is on the Foscarnet page.

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