Interazioni tra farmaci
Hydroxycarbamide + Stavudine
Gravità: Controindicata
Hydroxycarbamide and Stavudine: contraindicated interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Hydroxycarbamide with stavudine has been linked to fatal and nonfatal pancreatitis, hepatotoxicity and severe peripheral neuropathy. Hepatic failure and lactic acidosis are also of concern.
Cosa significa questa interazione in parole semplici
Hydroxycarbamide and Stavudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Hydroxycarbamide belongs to Oncology; Stavudine belongs to Anti Virals.
Perché avviene
Additive mitochondrial and organ toxicity, with hydroxycarbamide possibly increasing stavudine-related toxicity.
Cosa fare
Do not combine; switch to a safer antiretroviral regimen. Monitor liver enzymes, lipase and neuropathy symptoms if exposure has occurred.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Hydroxycarbamide e Stavudine, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Hydroxycarbamide
- Didanosine + Hydroxycarbamide Controindicata
Altre interazioni di Stavudine
- Didanosine + Stavudine Controindicata
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Stavudine Controindicata
- Stavudine + Zidovudine Controindicata
- Atidarsagene autotemcel + Stavudine Maggiore
- Betibeglogene autotemcel + Stavudine Maggiore
- Elivaldogene autotemcel + Stavudine Maggiore
Domande frequenti
Can I take Hydroxycarbamide with Stavudine?
MediHelp rates the interaction as contraindicated. Hydroxycarbamide and Stavudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Hydroxycarbamide with stavudine has been linked to fatal and nonfatal pancreatitis, hepatotoxicity and severe peripheral neuropathy. Hepatic failure and lactic acidosis are also of concern.
How serious is the interaction between Hydroxycarbamide and Stavudine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; switch to a safer antiretroviral regimen. Monitor liver enzymes, lipase and neuropathy symptoms if exposure has occurred.
What other medicines interact with Hydroxycarbamide?
MediHelp also lists interactions of Hydroxycarbamide with, for example, Didanosine. The full list is on the Hydroxycarbamide page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
