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Interazioni tra farmaci

Ifosfamide + Sargramostim

Gravità: Moderata

Ifosfamide and Sargramostim: moderate interaction.

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Sintesi

Sargramostim stimulates proliferation of myeloid progenitor cells, which makes them more susceptible to damage from cytotoxic drugs. Giving it close to ifosfamide may worsen myelosuppression or blunt its intended benefit.

Cosa significa questa interazione in parole semplici

Ifosfamide and Sargramostim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Ifosfamide belongs to Oncology; Sargramostim belongs to Miscellaneous.

Livello di evidenza: Moderate

Perché avviene

Growth factor-driven cycling of hematopoietic progenitors increases their sensitivity to cytotoxic chemotherapy.

Cosa fare

Do not give sargramostim within 24 hours before or after ifosfamide. Monitor blood counts throughout treatment.

Cosa chiedere al farmacista

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Ifosfamide with Sargramostim?

MediHelp rates the interaction as moderate. Ifosfamide and Sargramostim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sargramostim stimulates proliferation of myeloid progenitor cells, which makes them more susceptible to damage from cytotoxic drugs. Giving it close to ifosfamide may worsen myelosuppression or blunt its intended benefit.

How serious is the interaction between Ifosfamide and Sargramostim?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give sargramostim within 24 hours before or after ifosfamide. Monitor blood counts throughout treatment.

What other medicines interact with Ifosfamide?

MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.

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