Interazioni tra farmaci
Imatinib + Lonafarnib
Gravità: Controindicata
Imatinib and Lonafarnib: contraindicated interaction.
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Sintesi
Lonafarnib is a sensitive CYP3A4 substrate, and imatinib inhibits CYP3A4. Increased lonafarnib exposure can worsen gastrointestinal toxicity, hepatic effects, and QT-related risks. Labeling contraindicates strong or moderate CYP3A inhibitors.
Cosa significa questa interazione in parole semplici
Imatinib and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Imatinib belongs to Oncology; Lonafarnib belongs to Miscellaneous.
Perché avviene
Imatinib inhibits CYP3A4 metabolism of lonafarnib, raising its systemic exposure.
Cosa fare
Avoid the combination. If a CYP3A inhibitor is essential, follow labeling for temporary lonafarnib dose reduction and monitor for toxicity.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Imatinib
- Imatinib + Lomitapide Controindicata
- Amobarbital + Imatinib Maggiore
- Apalutamide + Imatinib Maggiore
- Avapritinib + Imatinib Maggiore
- Benzhydrocodone / acetaminophen + Imatinib Maggiore
- Bosutinib + Imatinib Maggiore
Altre interazioni di Lonafarnib
- Alfuzosin + Lonafarnib Controindicata
- Amobarbital + Lonafarnib Controindicata
- Apalutamide + Lonafarnib Controindicata
- Bosentan + Lonafarnib Controindicata
- Carbamazepine + Lonafarnib Controindicata
- Clarithromycin + Lonafarnib Controindicata
Domande frequenti
Can I take Imatinib with Lonafarnib?
MediHelp rates the interaction as contraindicated. Imatinib and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a sensitive CYP3A4 substrate, and imatinib inhibits CYP3A4. Increased lonafarnib exposure can worsen gastrointestinal toxicity, hepatic effects, and QT-related risks. Labeling contraindicates strong or moderate CYP3A inhibitors.
How serious is the interaction between Imatinib and Lonafarnib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If a CYP3A inhibitor is essential, follow labeling for temporary lonafarnib dose reduction and monitor for toxicity.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Amobarbital, Apalutamide. The full list is on the Imatinib page.
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