Interazioni tra farmaci
Imipramine + Safinamide
Gravità: Controindicata
Imipramine and Safinamide: contraindicated interaction.
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Sintesi
Safinamide is a reversible MAO-B inhibitor and imipramine blocks serotonin and noradrenaline reuptake. The combination can cause life-threatening serotonin syndrome.
Cosa significa questa interazione in parole semplici
Imipramine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Imipramine belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Perché avviene
MAO-B inhibition plus monoamine reuptake inhibition
Cosa fare
Contraindicated; allow at least 5 half-lives of safinamide (about 7 days) before starting imipramine and 14 days after stopping a tricyclic before safinamide.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Imipramine
- Dronedarone + Imipramine Controindicata
- Imipramine + Isocarboxazid Controindicata
- Imipramine + Phenelzine Controindicata
- Imipramine + Pimozide Controindicata
- Imipramine + Rasagiline Controindicata
- Imipramine + Selegiline Controindicata
Altre interazioni di Safinamide
- Amitriptyline + Safinamide Controindicata
- Amoxapine + Safinamide Controindicata
- Amphetamine polistirex + Safinamide Controindicata
- Clomipramine + Safinamide Controindicata
- Cyclobenzaprine + Safinamide Controindicata
- Desipramine + Safinamide Controindicata
Domande frequenti
Can I take Imipramine with Safinamide?
MediHelp rates the interaction as contraindicated. Imipramine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Safinamide is a reversible MAO-B inhibitor and imipramine blocks serotonin and noradrenaline reuptake. The combination can cause life-threatening serotonin syndrome.
How serious is the interaction between Imipramine and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; allow at least 5 half-lives of safinamide (about 7 days) before starting imipramine and 14 days after stopping a tricyclic before safinamide.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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