Interazioni tra farmaci
Clomipramine + Safinamide
Gravità: Controindicata
Clomipramine and Safinamide: contraindicated interaction.
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Sintesi
Safinamide is a reversible MAO-B inhibitor and clomipramine blocks serotonin and noradrenaline reuptake. Together they can produce serotonin syndrome, and safinamide labelling advises against tricyclic antidepressants.
Cosa significa questa interazione in parole semplici
Clomipramine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clomipramine belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Perché avviene
MAO-B inhibition plus monoamine reuptake inhibition
Cosa fare
Do not co-administer; allow at least 5 days after stopping safinamide before starting clomipramine, and 14 days after stopping clomipramine before safinamide.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Clomipramine
- Arsenic trioxide + Clomipramine Controindicata
- Clomipramine + Dofetilide Controindicata
- Clomipramine + Droperidol Controindicata
- Clomipramine + Isocarboxazid Controindicata
- Clomipramine + Methylene blue Controindicata
- Clomipramine + Pentamidine Controindicata
Altre interazioni di Safinamide
- Amitriptyline + Safinamide Controindicata
- Amoxapine + Safinamide Controindicata
- Amphetamine polistirex + Safinamide Controindicata
- Cyclobenzaprine + Safinamide Controindicata
- Desipramine + Safinamide Controindicata
- Desvenlafaxine + Safinamide Controindicata
Domande frequenti
Can I take Clomipramine with Safinamide?
MediHelp rates the interaction as contraindicated. Clomipramine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Safinamide is a reversible MAO-B inhibitor and clomipramine blocks serotonin and noradrenaline reuptake. Together they can produce serotonin syndrome, and safinamide labelling advises against tricyclic antidepressants.
How serious is the interaction between Clomipramine and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; allow at least 5 days after stopping safinamide before starting clomipramine, and 14 days after stopping clomipramine before safinamide.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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