Interazioni tra farmaci
Imipramine + Selegiline
Gravità: Controindicata
Imipramine and Selegiline: contraindicated interaction.
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Sintesi
Selegiline inhibits MAO-B and loses selectivity at higher doses, while imipramine blocks serotonin and noradrenaline reuptake. Serotonin syndrome and hypertensive reactions have been reported.
Cosa significa questa interazione in parole semplici
Imipramine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Imipramine belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Perché avviene
MAO inhibition plus monoamine reuptake inhibition
Cosa fare
Do not combine; allow at least 14 days after stopping selegiline before starting imipramine and the reverse.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Imipramine
- Dronedarone + Imipramine Controindicata
- Imipramine + Isocarboxazid Controindicata
- Imipramine + Phenelzine Controindicata
- Imipramine + Pimozide Controindicata
- Imipramine + Rasagiline Controindicata
- Imipramine + Safinamide Controindicata
Altre interazioni di Selegiline
- Amitriptyline + Selegiline Controindicata
- Amoxapine + Selegiline Controindicata
- Atomoxetine + Selegiline Controindicata
- Benzphetamine + Selegiline Controindicata
- Brimonidine + Selegiline Controindicata
- Buprenorphine long-acting + Selegiline Controindicata
Domande frequenti
Can I take Imipramine with Selegiline?
MediHelp rates the interaction as contraindicated. Imipramine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline inhibits MAO-B and loses selectivity at higher doses, while imipramine blocks serotonin and noradrenaline reuptake. Serotonin syndrome and hypertensive reactions have been reported.
How serious is the interaction between Imipramine and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days after stopping selegiline before starting imipramine and the reverse.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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