Interazioni tra farmaci
Insulin degludec + Vitamin b3
Gravità: Moderata
Insulin degludec and Vitamin b3: moderate interaction.
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Sintesi
High-dose niacin, as used for lipid lowering, can impair glucose tolerance and raise blood glucose. This may reduce the glucose-lowering effect of insulin degludec and lead to worsened glycemic control in patients with diabetes.
Cosa significa questa interazione in parole semplici
Insulin degludec and Vitamin b3 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec belongs to Endocrine; Vitamin b3 belongs to Gastrointestinal Tract.
Perché avviene
Niacin induces insulin resistance and increases hepatic glucose output, which opposes the glucose-lowering action of insulin.
Cosa fare
Monitor blood glucose more frequently when starting, adjusting or stopping high-dose niacin. Increase the insulin dose as needed and reduce it again if niacin is withdrawn.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Insulin degludec
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- Insulin degludec + Metformin-pioglitazone Maggiore
Domande frequenti
Can I take Insulin degludec with Vitamin b3?
MediHelp rates the interaction as moderate. Insulin degludec and Vitamin b3 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose niacin, as used for lipid lowering, can impair glucose tolerance and raise blood glucose. This may reduce the glucose-lowering effect of insulin degludec and lead to worsened glycemic control in patients with diabetes.
How serious is the interaction between Insulin degludec and Vitamin b3?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting, adjusting or stopping high-dose niacin. Increase the insulin dose as needed and reduce it again if niacin is withdrawn.
What other medicines interact with Vitamin b3?
MediHelp also lists interactions of Vitamin b3 with, for example, Lovastatin, Simvastatin, Atorvastatin. The full list is on the Vitamin b3 page.
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