Interazioni tra farmaci
Ketoconazole + Pralsetinib
Gravità: Maggiore
Ketoconazole and Pralsetinib: major interaction.
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Sintesi
Ketoconazole increases pralsetinib exposure and may intensify adverse effects such as hepatotoxicity, hypertension, hemorrhage, pneumonitis and myelosuppression.
Cosa significa questa interazione in parole semplici
Ketoconazole and Pralsetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketoconazole belongs to Anti Fungals; Pralsetinib belongs to Oncology.
Perché avviene
Combined inhibition of CYP3A4 metabolism and P-glycoprotein efflux of pralsetinib.
Cosa fare
Avoid the combination if possible; if required, reduce the pralsetinib dose per labeling and restore it after 3 to 5 half-lives of the inhibitor have elapsed post-discontinuation.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Ketoconazole
- Alfuzosin + Ketoconazole Controindicata
- Alprazolam + Ketoconazole Controindicata
- Avanafil + Ketoconazole Controindicata
- Conivaptan + Ketoconazole Controindicata
- Dihydroergotamine intranasal + Ketoconazole Controindicata
- Dihydroergotamine + Ketoconazole Controindicata
Altre interazioni di Pralsetinib
- Amobarbital + Pralsetinib Maggiore
- Apalutamide + Pralsetinib Maggiore
- Carbamazepine + Pralsetinib Maggiore
- Chloramphenicol + Pralsetinib Maggiore
- Clarithromycin + Pralsetinib Maggiore
- Efavirenz + Pralsetinib Maggiore
Domande frequenti
Can I take Ketoconazole with Pralsetinib?
MediHelp rates the interaction as major. Ketoconazole and Pralsetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketoconazole increases pralsetinib exposure and may intensify adverse effects such as hepatotoxicity, hypertension, hemorrhage, pneumonitis and myelosuppression.
How serious is the interaction between Ketoconazole and Pralsetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if required, reduce the pralsetinib dose per labeling and restore it after 3 to 5 half-lives of the inhibitor have elapsed post-discontinuation.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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