Interazioni tra farmaci
Ketorolac intranasal + Vitamin k1
Gravità: Moderata
Ketorolac intranasal and Vitamin k1: moderate interaction.
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Sintesi
Ketorolac inhibits platelet function and increases bleeding risk, which may work against the aim of phytonadione in bleeding or coagulopathy. Systemic exposure from the nasal form is lower than oral or injected ketorolac but still present.
Cosa significa questa interazione in parole semplici
Ketorolac intranasal and Vitamin k1 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perché avviene
Ketorolac's reversible COX-1 inhibition impairs platelet aggregation, a pharmacodynamic effect not corrected by vitamin K.
Cosa fare
Avoid ketorolac in patients with active bleeding or vitamin K-responsive coagulopathy; choose a non-NSAID analgesic.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Vitamin k1
- Vitamin k1 + Warfarin Maggiore
- Cholestyramine + Vitamin k1 Moderata
- Colestipol + Vitamin k1 Moderata
- Mineral oil + Vitamin k1 Moderata
- Orlistat + Vitamin k1 Moderata
- Aescin + Vitamin k1 Minore
Domande frequenti
Can I take Ketorolac intranasal with Vitamin k1?
MediHelp rates the interaction as moderate. Ketorolac intranasal and Vitamin k1 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac inhibits platelet function and increases bleeding risk, which may work against the aim of phytonadione in bleeding or coagulopathy. Systemic exposure from the nasal form is lower than oral or injected ketorolac but still present.
How serious is the interaction between Ketorolac intranasal and Vitamin k1?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ketorolac in patients with active bleeding or vitamin K-responsive coagulopathy; choose a non-NSAID analgesic.
What other medicines interact with Vitamin k1?
MediHelp also lists interactions of Vitamin k1 with, for example, Warfarin, Cholestyramine, Colestipol. The full list is on the Vitamin k1 page.
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