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Interazioni tra farmaci

Orlistat + Vitamin k1

Gravità: Moderata

Orlistat and Vitamin k1: moderate interaction.

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Sintesi

Orlistat decreases absorption of fat-soluble vitamins including vitamin K, and reduced vitamin K status may occur with prolonged use. This matters most for patients taking warfarin, in whom INR may rise.

Cosa significa questa interazione in parole semplici

Orlistat and Vitamin k1 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Orlistat belongs to Miscellaneous; Vitamin k1 belongs to Cardiovascular.

Livello di evidenza: Moderate

Perché avviene

Inhibition of gastrointestinal lipase reduces absorption of fat-soluble vitamins.

Cosa fare

Take vitamin K-containing supplements at least 2 hours apart from orlistat. Monitor INR in patients on vitamin K antagonists.

Cosa chiedere al farmacista

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Orlistat with Vitamin k1?

MediHelp rates the interaction as moderate. Orlistat and Vitamin k1 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orlistat decreases absorption of fat-soluble vitamins including vitamin K, and reduced vitamin K status may occur with prolonged use. This matters most for patients taking warfarin, in whom INR may rise.

How serious is the interaction between Orlistat and Vitamin k1?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take vitamin K-containing supplements at least 2 hours apart from orlistat. Monitor INR in patients on vitamin K antagonists.

What other medicines interact with Orlistat?

MediHelp also lists interactions of Orlistat with, for example, Cyclosporine, Cyclosporin, Triheptanoin. The full list is on the Orlistat page.

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