Interazioni tra farmaci
Lapatinib + Saquinavir
Gravità: Controindicata
Lapatinib and Saquinavir: contraindicated interaction.
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Sintesi
Saquinavir, usually boosted with ritonavir, is a strong CYP3A4 inhibitor that can greatly raise lapatinib exposure. Both drugs prolong the QT interval, so the risk of torsades de pointes and lapatinib toxicity increases.
Cosa significa questa interazione in parole semplici
Lapatinib and Saquinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Saquinavir inhibits CYP3A4 metabolism of lapatinib, with additive QT prolongation.
Cosa fare
Avoid the combination and choose an alternative antiretroviral or kinase inhibitor. If it cannot be avoided, reduce lapatinib dose substantially and monitor ECG closely.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Lapatinib
- Dofetilide + Lapatinib Controindicata
- Ibutilide + Lapatinib Controindicata
- Lapatinib + Pimozide Controindicata
- Lapatinib + Thioridazine Controindicata
- Adagrasib + Lapatinib Maggiore
- Amiodarone + Lapatinib Maggiore
Domande frequenti
Can I take Lapatinib with Saquinavir?
MediHelp rates the interaction as contraindicated. Lapatinib and Saquinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Saquinavir, usually boosted with ritonavir, is a strong CYP3A4 inhibitor that can greatly raise lapatinib exposure. Both drugs prolong the QT interval, so the risk of torsades de pointes and lapatinib toxicity increases.
How serious is the interaction between Lapatinib and Saquinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative antiretroviral or kinase inhibitor. If it cannot be avoided, reduce lapatinib dose substantially and monitor ECG closely.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
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