Interazioni tra farmaci
Lapatinib + Thioridazine
Gravità: Controindicata
Lapatinib and Thioridazine: contraindicated interaction.
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Sintesi
Thioridazine carries a strong QT-prolonging effect and lapatinib can also lengthen the QT interval. Combined use markedly raises the risk of torsades de pointes.
Cosa significa questa interazione in parole semplici
Lapatinib and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lapatinib belongs to Oncology; Thioridazine belongs to Central Nervous System.
Perché avviene
Additive prolongation of cardiac repolarization through cardiac potassium channel effects.
Cosa fare
Avoid using the two together and select an alternative antipsychotic with lower QT liability.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Thioridazine
- Abiraterone + Thioridazine Controindicata
- Adagrasib + Thioridazine Controindicata
- Amiodarone + Thioridazine Controindicata
- Amisulpride + Thioridazine Controindicata
- Amitriptyline + Thioridazine Controindicata
- Amoxapine + Thioridazine Controindicata
Altre interazioni di Lapatinib
- Dofetilide + Lapatinib Controindicata
- Ibutilide + Lapatinib Controindicata
- Lapatinib + Pimozide Controindicata
- Lapatinib + Saquinavir Controindicata
- Adagrasib + Lapatinib Maggiore
- Amiodarone + Lapatinib Maggiore
Domande frequenti
Can I take Lapatinib with Thioridazine?
MediHelp rates the interaction as contraindicated. Lapatinib and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine carries a strong QT-prolonging effect and lapatinib can also lengthen the QT interval. Combined use markedly raises the risk of torsades de pointes.
How serious is the interaction between Lapatinib and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using the two together and select an alternative antipsychotic with lower QT liability.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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