Interazioni tra farmaci
Amiodarone + Lapatinib
Gravità: Maggiore
Amiodarone and Lapatinib: major interaction.
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Sintesi
Lapatinib can prolong the QT interval and amiodarone strongly does so as well, increasing the risk of torsades de pointes. Amiodarone may also modestly raise lapatinib exposure through CYP3A4 and P-glycoprotein effects.
Cosa significa questa interazione in parole semplici
Amiodarone and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Lapatinib belongs to Oncology.
Perché avviene
Additive QT prolongation, plus possible inhibition of lapatinib metabolism and efflux by amiodarone.
Cosa fare
Avoid combining where possible. If necessary, monitor ECG and electrolytes and watch for lapatinib toxicity such as diarrhea or hepatotoxicity.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Amiodarone
- Amiodarone + Amisulpride Controindicata
- Amiodarone + Arsenic trioxide Controindicata
- Amiodarone + Dofetilide Controindicata
- Amiodarone + Dronedarone Controindicata
- Amiodarone + Droperidol Controindicata
- Amiodarone + Eliglustat Controindicata
Altre interazioni di Lapatinib
- Dofetilide + Lapatinib Controindicata
- Ibutilide + Lapatinib Controindicata
- Lapatinib + Pimozide Controindicata
- Lapatinib + Saquinavir Controindicata
- Lapatinib + Thioridazine Controindicata
- Adagrasib + Lapatinib Maggiore
Domande frequenti
Can I take Amiodarone with Lapatinib?
MediHelp rates the interaction as major. Amiodarone and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lapatinib can prolong the QT interval and amiodarone strongly does so as well, increasing the risk of torsades de pointes. Amiodarone may also modestly raise lapatinib exposure through CYP3A4 and P-glycoprotein effects.
How serious is the interaction between Amiodarone and Lapatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible. If necessary, monitor ECG and electrolytes and watch for lapatinib toxicity such as diarrhea or hepatotoxicity.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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