Interazioni tra farmaci
Levofloxacin + Thioridazine
Gravità: Controindicata
Levofloxacin and Thioridazine: contraindicated interaction.
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Sintesi
Thioridazine is strongly associated with dose-related QT prolongation and torsades de pointes, and its labeling contraindicates use with other QT-prolonging drugs. Adding levofloxacin compounds the arrhythmia risk.
Cosa significa questa interazione in parole semplici
Levofloxacin and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levofloxacin belongs to Anti Bacterial; Thioridazine belongs to Central Nervous System.
Perché avviene
Additive blockade of cardiac potassium channels causing marked delay in ventricular repolarization.
Cosa fare
Do not co-administer; select an antibiotic without QT liability. If a fluoroquinolone is unavoidable, thioridazine should be held under specialist guidance.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Levofloxacin
- Dronedarone + Levofloxacin Controindicata
- Ibutilide + Levofloxacin Controindicata
- Levofloxacin + Vandetanib Controindicata
- Levofloxacin + Ziprasidone Controindicata
- Adagrasib + Levofloxacin Maggiore
- Amiodarone + Levofloxacin Maggiore
Altre interazioni di Thioridazine
- Abiraterone + Thioridazine Controindicata
- Adagrasib + Thioridazine Controindicata
- Amiodarone + Thioridazine Controindicata
- Amisulpride + Thioridazine Controindicata
- Amitriptyline + Thioridazine Controindicata
- Amoxapine + Thioridazine Controindicata
Domande frequenti
Can I take Levofloxacin with Thioridazine?
MediHelp rates the interaction as contraindicated. Levofloxacin and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine is strongly associated with dose-related QT prolongation and torsades de pointes, and its labeling contraindicates use with other QT-prolonging drugs. Adding levofloxacin compounds the arrhythmia risk.
How serious is the interaction between Levofloxacin and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; select an antibiotic without QT liability. If a fluoroquinolone is unavoidable, thioridazine should be held under specialist guidance.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Vandetanib. The full list is on the Levofloxacin page.
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