Interazioni tra farmaci
Lomitapide + Micafungin
Gravità: Moderata
Lomitapide and Micafungin: moderate interaction.
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Sintesi
Lomitapide is highly dependent on CYP3A4 for clearance and its exposure rises markedly with inhibitors. Micafungin is only a weak inhibitor, so the effect is likely small, but increased lomitapide could worsen hepatotoxicity and gastrointestinal effects.
Cosa significa questa interazione in parole semplici
Lomitapide and Micafungin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomitapide belongs to Cardiovascular; Micafungin belongs to Anti Fungals.
Perché avviene
Possible weak inhibition of CYP3A4-mediated lomitapide metabolism by micafungin.
Cosa fare
Monitor liver enzymes and tolerability; keep the lomitapide dose within labeled limits for use with weak CYP3A4 inhibitors.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Micafungin
- Micafungin + Saccharomyces boulardii Moderata
- Micafungin + Sirolimus Moderata
- Avapritinib + Micafungin Minore
- Finerenone + Micafungin Minore
- Isavuconazonium + Micafungin Minore
- Ivacaftor + Micafungin Minore
Altre interazioni di Lomitapide
- Aprepitant + Lomitapide Controindicata
- Clarithromycin + Lomitapide Controindicata
- Crizotinib + Lomitapide Controindicata
- Diltiazem + Lomitapide Controindicata
- Efavirenz + Lomitapide Controindicata
- Ensitrelvir + Lomitapide Controindicata
Domande frequenti
Can I take Lomitapide with Micafungin?
MediHelp rates the interaction as moderate. Lomitapide and Micafungin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide is highly dependent on CYP3A4 for clearance and its exposure rises markedly with inhibitors. Micafungin is only a weak inhibitor, so the effect is likely small, but increased lomitapide could worsen hepatotoxicity and gastrointestinal effects.
How serious is the interaction between Lomitapide and Micafungin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and tolerability; keep the lomitapide dose within labeled limits for use with weak CYP3A4 inhibitors.
What other medicines interact with Micafungin?
MediHelp also lists interactions of Micafungin with, for example, Saccharomyces boulardii, Sirolimus, Avapritinib. The full list is on the Micafungin page.
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