Interazioni tra farmaci
Isavuconazonium + Micafungin
Gravità: Minore
Isavuconazonium and Micafungin: minor interaction.
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Sintesi
Micafungin is a weak CYP3A4 inhibitor, and isavuconazole is a CYP3A4 substrate, so a small rise in isavuconazole exposure is theoretically possible. This is unlikely to be clinically important, and the two antifungals are sometimes used together.
Cosa significa questa interazione in parole semplici
Isavuconazonium and Micafungin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isavuconazonium belongs to Anti Fungals; Micafungin belongs to Anti Fungals.
Perché avviene
Theoretical weak CYP3A4 inhibition by micafungin reducing isavuconazole clearance.
Cosa fare
No empirical dose adjustment is needed; monitor for isavuconazole adverse effects such as liver enzyme elevation.
Cosa chiedere al farmacista
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Altre interazioni di Micafungin
- Lomitapide + Micafungin Moderata
- Micafungin + Saccharomyces boulardii Moderata
- Micafungin + Sirolimus Moderata
- Avapritinib + Micafungin Minore
- Finerenone + Micafungin Minore
- Ivacaftor + Micafungin Minore
Altre interazioni di Isavuconazonium
- Amobarbital + Isavuconazonium Controindicata
- Apalutamide + Isavuconazonium Controindicata
- Carbamazepine + Isavuconazonium Controindicata
- Cisapride + Isavuconazonium Controindicata
- Efavirenz + Isavuconazonium Controindicata
- Enzalutamide + Isavuconazonium Controindicata
Domande frequenti
Can I take Isavuconazonium with Micafungin?
MediHelp rates the interaction as minor. Isavuconazonium and Micafungin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Micafungin is a weak CYP3A4 inhibitor, and isavuconazole is a CYP3A4 substrate, so a small rise in isavuconazole exposure is theoretically possible. This is unlikely to be clinically important, and the two antifungals are sometimes used together.
How serious is the interaction between Isavuconazonium and Micafungin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose adjustment is needed; monitor for isavuconazole adverse effects such as liver enzyme elevation.
What other medicines interact with Micafungin?
MediHelp also lists interactions of Micafungin with, for example, Lomitapide, Saccharomyces boulardii, Sirolimus. The full list is on the Micafungin page.
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