Drug interactions
Lomustine + Measles mumps rubella and varicella vaccine live
Severity: Contraindicated
Lomustine and Measles mumps rubella and varicella vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combined live MMRV vaccine carries a risk of disseminated vaccine-strain infection in patients immunosuppressed by lomustine, and immunogenicity is reduced.
What this interaction means in plain words
Lomustine and Measles mumps rubella and varicella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Cytotoxic immunosuppression impairs control of live vaccine virus replication and reduces the immune response.
What to do
Avoid during lomustine therapy and until immune recovery, generally at least 3 months after treatment. Revaccinate once immune function is restored.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles vaccine Contraindicated
Frequently asked questions
Can I take Lomustine with Measles mumps rubella and varicella vaccine live?
MediHelp rates the interaction as contraindicated. Lomustine and Measles mumps rubella and varicella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The combined live MMRV vaccine carries a risk of disseminated vaccine-strain infection in patients immunosuppressed by lomustine, and immunogenicity is reduced.
How serious is the interaction between Lomustine and Measles mumps rubella and varicella vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during lomustine therapy and until immune recovery, generally at least 3 months after treatment. Revaccinate once immune function is restored.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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