Interazioni tra farmaci
Maprotiline + Phenelzine
Gravità: Controindicata
Maprotiline and Phenelzine: contraindicated interaction.
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Sintesi
Maprotiline, a noradrenergic tetracyclic, combined with the MAOI phenelzine can produce hypertensive crisis, serotonin-like toxicity and severe agitation. Serious reactions may occur.
Cosa significa questa interazione in parole semplici
Maprotiline and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Maprotiline belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Perché avviene
MAO inhibition combined with norepinephrine reuptake blockade leads to excess monoamine activity.
Cosa fare
Do not combine; allow at least 14 days after stopping phenelzine before maprotiline and an appropriate interval in reverse.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Maprotiline
- Arsenic trioxide + Maprotiline Controindicata
- Disopyramide + Maprotiline Controindicata
- Dofetilide + Maprotiline Controindicata
- Ibutilide + Maprotiline Controindicata
- Isocarboxazid + Maprotiline Controindicata
- Maprotiline + Methylene blue Controindicata
Altre interazioni di Phenelzine
- 5-HTP + Phenelzine Controindicata
- Amitriptyline + Phenelzine Controindicata
- Amoxapine + Phenelzine Controindicata
- Atomoxetine + Phenelzine Controindicata
- Benzphetamine + Phenelzine Controindicata
- Brimonidine + Phenelzine Controindicata
Domande frequenti
Can I take Maprotiline with Phenelzine?
MediHelp rates the interaction as contraindicated. Maprotiline and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Maprotiline, a noradrenergic tetracyclic, combined with the MAOI phenelzine can produce hypertensive crisis, serotonin-like toxicity and severe agitation. Serious reactions may occur.
How serious is the interaction between Maprotiline and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days after stopping phenelzine before maprotiline and an appropriate interval in reverse.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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