Interazioni tra farmaci
Ibutilide + Maprotiline
Gravità: Controindicata
Ibutilide and Maprotiline: contraindicated interaction.
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Sintesi
Ibutilide markedly prolongs repolarisation and carries a significant risk of torsades de pointes. Adding maprotiline, which also lengthens the QT interval, further increases the likelihood of life-threatening ventricular arrhythmia.
Cosa significa questa interazione in parole semplici
Ibutilide and Maprotiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ibutilide belongs to Cardiovascular; Maprotiline belongs to Central Nervous System.
Perché avviene
Additive pharmacodynamic prolongation of the QT interval.
Cosa fare
Do not give ibutilide to patients taking maprotiline; consider an alternative cardioversion strategy such as electrical cardioversion. Review the need for maprotiline if rhythm control with QT-prolonging agents is planned.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Maprotiline
- Arsenic trioxide + Maprotiline Controindicata
- Disopyramide + Maprotiline Controindicata
- Dofetilide + Maprotiline Controindicata
- Isocarboxazid + Maprotiline Controindicata
- Maprotiline + Methylene blue Controindicata
- Maprotiline + Phenelzine Controindicata
Altre interazioni di Ibutilide
- Amiodarone + Ibutilide Controindicata
- Amisulpride + Ibutilide Controindicata
- Chlorpromazine + Ibutilide Controindicata
- Clarithromycin + Ibutilide Controindicata
- Desipramine + Ibutilide Controindicata
- Dolasetron + Ibutilide Controindicata
Domande frequenti
Can I take Ibutilide with Maprotiline?
MediHelp rates the interaction as contraindicated. Ibutilide and Maprotiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ibutilide markedly prolongs repolarisation and carries a significant risk of torsades de pointes. Adding maprotiline, which also lengthens the QT interval, further increases the likelihood of life-threatening ventricular arrhythmia.
How serious is the interaction between Ibutilide and Maprotiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give ibutilide to patients taking maprotiline; consider an alternative cardioversion strategy such as electrical cardioversion. Review the need for maprotiline if rhythm control with QT-prolonging agents is planned.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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