Interazioni tra farmaci
Arsenic trioxide + Maprotiline
Gravità: Controindicata
Arsenic trioxide and Maprotiline: contraindicated interaction.
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Sintesi
Arsenic trioxide causes marked QT prolongation and torsades de pointes, and maprotiline adds to this risk. The combination can cause life-threatening ventricular arrhythmias.
Cosa significa questa interazione in parole semplici
Arsenic trioxide and Maprotiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Arsenic trioxide belongs to Oncology; Maprotiline belongs to Central Nervous System.
Perché avviene
Additive QT prolongation through cardiac repolarization effects.
Cosa fare
Avoid the combination and use a non-QT-prolonging antidepressant during arsenic trioxide therapy. If it is unavoidable, perform continuous ECG monitoring and keep potassium and magnesium replete.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Maprotiline
- Disopyramide + Maprotiline Controindicata
- Dofetilide + Maprotiline Controindicata
- Ibutilide + Maprotiline Controindicata
- Isocarboxazid + Maprotiline Controindicata
- Maprotiline + Methylene blue Controindicata
- Maprotiline + Phenelzine Controindicata
Altre interazioni di Arsenic trioxide
- Amiodarone + Arsenic trioxide Controindicata
- Amisulpride + Arsenic trioxide Controindicata
- Arsenic trioxide + Clomipramine Controindicata
- Arsenic trioxide + Dronedarone Controindicata
- Arsenic trioxide + Fluphenazine Controindicata
- Arsenic trioxide + Gemifloxacin Controindicata
Domande frequenti
Can I take Arsenic trioxide with Maprotiline?
MediHelp rates the interaction as contraindicated. Arsenic trioxide and Maprotiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Arsenic trioxide causes marked QT prolongation and torsades de pointes, and maprotiline adds to this risk. The combination can cause life-threatening ventricular arrhythmias.
How serious is the interaction between Arsenic trioxide and Maprotiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-QT-prolonging antidepressant during arsenic trioxide therapy. If it is unavoidable, perform continuous ECG monitoring and keep potassium and magnesium replete.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Maprotiline page.
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