Interazioni tra farmaci
Mavacamten + Ticlopidine
Gravità: Controindicata
Mavacamten and Ticlopidine: contraindicated interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Ticlopidine inhibits CYP2C19, which is the main route of mavacamten metabolism, and may raise its exposure. Excess mavacamten can reduce ejection fraction and lead to heart failure from systolic dysfunction. The labeling contraindicates moderate to strong CYP2C19 inhibitors.
Cosa significa questa interazione in parole semplici
Mavacamten and Ticlopidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Mavacamten belongs to Cardiovascular; Ticlopidine belongs to Cardiovascular.
Perché avviene
Inhibition of CYP2C19 by ticlopidine reduces mavacamten clearance.
Cosa fare
Avoid the combination and choose an alternative antiplatelet drug if possible. If it cannot be avoided, monitor LVEF closely and consider mavacamten dose reduction or interruption.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Mavacamten e Ticlopidine, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Ticlopidine
- Abrocitinib + Ticlopidine Maggiore
- Acetylsalicylic acid + Ticlopidine Maggiore
- Apixaban + Ticlopidine Maggiore
- Aspirin / citric acid / sodium bicarbonate + Ticlopidine Maggiore
- Aspirin rectal + Ticlopidine Maggiore
- Aspirin + Ticlopidine Maggiore
Altre interazioni di Mavacamten
- Apalutamide + Mavacamten Controindicata
- Carbamazepine + Mavacamten Controindicata
- Clarithromycin + Mavacamten Controindicata
- Dexlansoprazole + Mavacamten Controindicata
- Efavirenz + Mavacamten Controindicata
- Enzalutamide + Mavacamten Controindicata
Domande frequenti
Can I take Mavacamten with Ticlopidine?
MediHelp rates the interaction as contraindicated. Mavacamten and Ticlopidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ticlopidine inhibits CYP2C19, which is the main route of mavacamten metabolism, and may raise its exposure. Excess mavacamten can reduce ejection fraction and lead to heart failure from systolic dysfunction. The labeling contraindicates moderate to strong CYP2C19 inhibitors.
How serious is the interaction between Mavacamten and Ticlopidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative antiplatelet drug if possible. If it cannot be avoided, monitor LVEF closely and consider mavacamten dose reduction or interruption.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Abrocitinib, Acetylsalicylic acid, Apixaban. The full list is on the Ticlopidine page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
