Interazioni tra farmaci
Measles mumps and rubella vaccine + Tisagenlecleucel
Gravità: Controindicata
Measles mumps and rubella vaccine and Tisagenlecleucel: contraindicated interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Tisagenlecleucel is a CAR-T cell therapy given after lymphodepleting chemotherapy and is associated with B-cell aplasia and prolonged immune suppression. Live vaccines can cause disseminated vaccine-strain infection in this setting.
Cosa significa questa interazione in parole semplici
Measles mumps and rubella vaccine and Tisagenlecleucel are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Measles mumps and rubella vaccine belongs to Miscellaneous; Tisagenlecleucel belongs to Oncology.
Perché avviene
Pharmacodynamic: lymphodepleting chemotherapy and CAR-T mediated B-cell depletion impair control of replicating live vaccine viruses.
Cosa fare
Do not give live vaccines from at least 6 weeks before lymphodepletion, during treatment, and until immune recovery is confirmed. Give inactivated vaccines according to specialist guidance after immune reconstitution.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Measles mumps and rubella vaccine e Tisagenlecleucel, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Controindicata
- Anakinra + Measles mumps and rubella vaccine Controindicata
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Controindicata
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Controindicata
- Azathioprine + Measles mumps and rubella vaccine Controindicata
- Basiliximab + Measles mumps and rubella vaccine Controindicata
Altre interazioni di Tisagenlecleucel
- Abatacept + Tisagenlecleucel Maggiore
- Adalimumab + Tisagenlecleucel Maggiore
- Anti-thymocyte + Tisagenlecleucel Maggiore
- Azathioprine + Tisagenlecleucel Maggiore
- Baricitinib + Tisagenlecleucel Maggiore
- Basiliximab + Tisagenlecleucel Maggiore
Domande frequenti
Can I take Measles mumps and rubella vaccine with Tisagenlecleucel?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine and Tisagenlecleucel are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tisagenlecleucel is a CAR-T cell therapy given after lymphodepleting chemotherapy and is associated with B-cell aplasia and prolonged immune suppression. Live vaccines can cause disseminated vaccine-strain infection in this setting.
How serious is the interaction between Measles mumps and rubella vaccine and Tisagenlecleucel?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live vaccines from at least 6 weeks before lymphodepletion, during treatment, and until immune recovery is confirmed. Give inactivated vaccines according to specialist guidance after immune reconstitution.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
