Interazioni tra farmaci
Measles mumps and rubella vaccine live + Melphalan
Gravità: Controindicata
Measles mumps and rubella vaccine live and Melphalan: contraindicated interaction.
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Sintesi
MMR vaccine contains live attenuated viruses, which can replicate without control in a patient immunosuppressed by melphalan. This can lead to disseminated vaccine-virus disease, and the vaccine response is also reduced.
Cosa significa questa interazione in parole semplici
Measles mumps and rubella vaccine live and Melphalan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Chemotherapy-induced immunosuppression allows unchecked replication of live attenuated virus and impairs the vaccine response.
Cosa fare
Avoid live vaccines during melphalan therapy and for at least 3 months after it ends, subject to immune recovery. Give live vaccines at least 4 weeks before starting chemotherapy when possible.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Melphalan
- Adenovirus types 4 and 7 live + Melphalan Controindicata
- Bcg vaccine live + Melphalan Controindicata
- Influenza virus vaccine quadrivalent intranasal + Melphalan Controindicata
- Measles mumps and rubella vaccine + Melphalan Controindicata
- Measles mumps rubella and varicella vaccine live + Melphalan Controindicata
- Measles vaccine + Melphalan Controindicata
Domande frequenti
Can I take Measles mumps and rubella vaccine live with Melphalan?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine live and Melphalan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MMR vaccine contains live attenuated viruses, which can replicate without control in a patient immunosuppressed by melphalan. This can lead to disseminated vaccine-virus disease, and the vaccine response is also reduced.
How serious is the interaction between Measles mumps and rubella vaccine live and Melphalan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during melphalan therapy and for at least 3 months after it ends, subject to immune recovery. Give live vaccines at least 4 weeks before starting chemotherapy when possible.
What other medicines interact with Melphalan?
MediHelp also lists interactions of Melphalan with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Melphalan page.
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