Interazioni tra farmaci
Methimazole + Phenindione
Gravità: Moderata
Methimazole and Phenindione: moderate interaction.
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Sintesi
Correcting hyperthyroidism with methimazole slows the catabolism of vitamin K-dependent clotting factors. As a result the anticoagulant effect of vitamin K antagonists such as phenindione tends to fall as the patient becomes euthyroid. Starting or stopping methimazole can therefore change INR control.
Cosa significa questa interazione in parole semplici
Methimazole and Phenindione can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perché avviene
Normalization of thyroid state reduces clotting factor turnover, which diminishes the response to vitamin K antagonists.
Cosa fare
Monitor INR more frequently when methimazole is started, changed or stopped. Adjust the phenindione dose to maintain the target INR.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Methimazole
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- Methimazole + Propylthiouracil Maggiore
- Methimazole + Sodium iodide i-131 Maggiore
- Iodinated glycerol + Methimazole Moderata
- Iodine + Methimazole Moderata
Domande frequenti
Can I take Methimazole with Phenindione?
MediHelp rates the interaction as moderate. Methimazole and Phenindione can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Correcting hyperthyroidism with methimazole slows the catabolism of vitamin K-dependent clotting factors. As a result the anticoagulant effect of vitamin K antagonists such as phenindione tends to fall as the patient becomes euthyroid. Starting or stopping methimazole can therefore change INR control.
How serious is the interaction between Methimazole and Phenindione?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more frequently when methimazole is started, changed or stopped. Adjust the phenindione dose to maintain the target INR.
What other medicines interact with Methimazole?
MediHelp also lists interactions of Methimazole with, for example, Carbamazepine, Clozapine, Propylthiouracil. The full list is on the Methimazole page.
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