Riferimento farmaci
Methimazole
Methimazole is a medicine in the class endocrine. It is used for graves disease.
- Classe del farmaco: Endocrine
- Indicato per: graves disease
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
In breve
- Classe del farmaco
- Endocrine
- Interazioni note
- 15 (Maggiore: 4 · Moderata: 8 · Minore: 3)
Per cosa si usa
Come agisce
Inhibits synthesis of thyroid hormone by blocking oxidation of iodine in thyroid gland; blocks synthesis of thyroxine (T4) and triiodothyronine (T3)
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Hyperthyroidism: Mild: 15 mg/day PO divided q8hr initially, Moderate: 30-40 mg/day PO divided q8hr initially
Gravidanza e allattamento
- Gravidanza
- Unsafe Crosses the placenta. 1st-trimester use is linked to rare birth defects (scalp skin defects, oesophageal or choanal atresia, abdominal wall defects). Propylthiouracil is usually preferred in the 1st trimester, then methimazole. Use the lowest dose; monitor maternal and fetal/newborn thyroid.
- Allattamento
- Safe Passes into milk, but a long-term study of 139 mothers found no infant toxicity, and doses up to 20 mg daily do not affect infant thyroid function. LactMed: some experts consider it the antithyroid drug of choice; take it right after a feed. US label: monitor thyroid function.
Effetti indesiderati segnalati
- Rash
- Hepatotoxicity
- Pruritus
- Alopecia
- Agranulocytosis
- Aplastic anemia
Chi deve prestare attenzione
- Antineutrophil cytoplasmic autoantibody (ANCA)-positive vasculitis reported; discontinue use in presence of vasculitis
- Concurrent administration of other agranulocytosis-causing drugs
- Significant bone marrow suppression may occur; use caution if administered with other agents known to cause myelosupression; discontinue if significan agranulocytosis
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (15)
- Carbamazepine + Methimazole Major
- Clozapine + Methimazole Major
- Methimazole + Propylthiouracil Major
- Methimazole + Sodium iodide i-131 Major
- Iodinated glycerol + Methimazole Moderate
- Iodine + Methimazole Moderate
- Lycopus + Methimazole Moderate
- Methimazole + Phenindione Moderate
- Methimazole + Potassium iodide Moderate
- Methimazole + Ropeginterferon alfa 2b Moderate
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per aprire la monografia completa di Methimazole: dosi, gravidanza e allattamento, effetti indesiderati, avvertenze e tutte le interazioni.
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altri farmaci della stessa classe
Domande frequenti
What is Methimazole used for?
Methimazole is a medicine in the class endocrine. It is used for Graves disease, Hyperthyroidism, Melasma.
What side effects have been reported with Methimazole?
Rash, Hepatotoxicity, Pruritus, Alopecia, Agranulocytosis, Aplastic anemia.
Can Methimazole be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Crosses the placenta. 1st-trimester use is linked to rare birth defects (scalp skin defects, oesophageal or choanal atresia, abdominal wall defects). Propylthiouracil is usually preferred in the 1st trimester, then methimazole. Use the lowest dose; monitor maternal and fetal/newborn thyroid. Breastfeeding: Safe. Passes into milk, but a long-term study of 139 mothers found no infant toxicity, and doses up to 20 mg daily do not affect infant thyroid function. LactMed: some experts consider it the antithyroid drug of choice; take it right after a feed. US label: monitor thyroid function.
What does Methimazole interact with?
MediHelp lists 15 known interactions for Methimazole. Major: 4 · Moderate: 8 · Minor: 3. The most serious include Carbamazepine, Clozapine, Propylthiouracil.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
