Interazioni tra farmaci
Methimazole + Propylthiouracil
Gravità: Maggiore
Methimazole and Propylthiouracil: major interaction.
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Sintesi
Both are thionamide antithyroid drugs with the same therapeutic action, so combining them offers no benefit. Each carries a risk of agranulocytosis, hepatotoxicity and other adverse effects, and duplication may add to this risk.
Cosa significa questa interazione in parole semplici
Methimazole and Propylthiouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Methimazole belongs to Endocrine; Propylthiouracil belongs to Endocrine.
Perché avviene
Therapeutic duplication with additive adverse effects, including myelosuppression, from two thionamides.
Cosa fare
Avoid concurrent use; use a single thionamide and monitor blood counts and liver function, with prompt evaluation of fever or sore throat.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Propylthiouracil
- Carbamazepine + Propylthiouracil Maggiore
- Clozapine + Propylthiouracil Maggiore
- Pexidartinib + Propylthiouracil Maggiore
- Pretomanid + Propylthiouracil Maggiore
- Propylthiouracil + Sodium iodide i-131 Maggiore
- Propylthiouracil + Valoctocogene roxaparvovec Maggiore
Altre interazioni di Methimazole
- Carbamazepine + Methimazole Maggiore
- Clozapine + Methimazole Maggiore
- Methimazole + Sodium iodide i-131 Maggiore
- Iodinated glycerol + Methimazole Moderata
- Iodine + Methimazole Moderata
- Lycopus + Methimazole Moderata
Domande frequenti
Can I take Methimazole with Propylthiouracil?
MediHelp rates the interaction as major. Methimazole and Propylthiouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are thionamide antithyroid drugs with the same therapeutic action, so combining them offers no benefit. Each carries a risk of agranulocytosis, hepatotoxicity and other adverse effects, and duplication may add to this risk.
How serious is the interaction between Methimazole and Propylthiouracil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; use a single thionamide and monitor blood counts and liver function, with prompt evaluation of fever or sore throat.
What other medicines interact with Propylthiouracil?
MediHelp also lists interactions of Propylthiouracil with, for example, Carbamazepine, Clozapine, Pexidartinib. The full list is on the Propylthiouracil page.
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