Interazioni tra farmaci
Nitroglycerin transdermal + Tadalafil
Gravità: Controindicata
Nitroglycerin transdermal and Tadalafil: contraindicated interaction.
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Sintesi
Tadalafil greatly amplifies the vasodilator effect of nitroglycerin patches, which deliver nitrate continuously. This can cause severe hypotension, syncope and cardiac ischemia.
Cosa significa questa interazione in parole semplici
Nitroglycerin transdermal and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Nitric oxide donation increases cGMP and tadalafil inhibits PDE5-mediated cGMP degradation, causing additive vasodilation.
Cosa fare
Avoid the combination; remove the patch and do not give nitrates within 48 hours of tadalafil. Use a non-nitrate antianginal if the patient needs ongoing tadalafil.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Tadalafil
- Amyl nitrite + Tadalafil Controindicata
- Isosorbide dinitrate + Tadalafil Controindicata
- Isosorbide mononitrate + Tadalafil Controindicata
- Nitroglycerin po + Tadalafil Controindicata
- Nitroglycerin rectal + Tadalafil Controindicata
- Nitroglycerin sublingual + Tadalafil Controindicata
Domande frequenti
Can I take Nitroglycerin transdermal with Tadalafil?
MediHelp rates the interaction as contraindicated. Nitroglycerin transdermal and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tadalafil greatly amplifies the vasodilator effect of nitroglycerin patches, which deliver nitrate continuously. This can cause severe hypotension, syncope and cardiac ischemia.
How serious is the interaction between Nitroglycerin transdermal and Tadalafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; remove the patch and do not give nitrates within 48 hours of tadalafil. Use a non-nitrate antianginal if the patient needs ongoing tadalafil.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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