Interazioni tra farmaci
Isosorbide dinitrate + Tadalafil
Gravità: Controindicata
Isosorbide dinitrate and Tadalafil: contraindicated interaction.
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Sintesi
Tadalafil inhibits PDE5 and isosorbide dinitrate releases nitric oxide, together causing a large rise in cGMP in vascular smooth muscle. Profound, sometimes fatal, hypotension and myocardial ischaemia may result.
Cosa significa questa interazione in parole semplici
Isosorbide dinitrate and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isosorbide dinitrate belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Perché avviene
PDE5 inhibition potentiates nitrate-induced cGMP vasodilation
Cosa fare
Contraindicated; do not give a nitrate within 48 hours of tadalafil, and use an alternative if both are required.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Tadalafil
- Amyl nitrite + Tadalafil Controindicata
- Isosorbide mononitrate + Tadalafil Controindicata
- Nitroglycerin po + Tadalafil Controindicata
- Nitroglycerin rectal + Tadalafil Controindicata
- Nitroglycerin sublingual + Tadalafil Controindicata
- Nitroglycerin transdermal + Tadalafil Controindicata
Altre interazioni di Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Controindicata
- Isosorbide dinitrate + Riociguat Controindicata
- Isosorbide dinitrate + Sildenafil Controindicata
- Isosorbide dinitrate + Vardenafil Controindicata
- Ergotamine + Isosorbide dinitrate Maggiore
- Isosorbide dinitrate + Methylergonovine Maggiore
Domande frequenti
Can I take Isosorbide dinitrate with Tadalafil?
MediHelp rates the interaction as contraindicated. Isosorbide dinitrate and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tadalafil inhibits PDE5 and isosorbide dinitrate releases nitric oxide, together causing a large rise in cGMP in vascular smooth muscle. Profound, sometimes fatal, hypotension and myocardial ischaemia may result.
How serious is the interaction between Isosorbide dinitrate and Tadalafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; do not give a nitrate within 48 hours of tadalafil, and use an alternative if both are required.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide mononitrate, Nitroglycerin po. The full list is on the Tadalafil page.
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